Genetic Framework for GATA Factor Function in Vascular Biology

ABSTRACT: Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Whereas the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. As many questions remain unanswered regarding GATA-2 function in the vascular biology realm, we used ChIP-seq and loss-of-function strategies to define the GATA-2-instigated genetic network in human endothelial cells. By contrast to erythroid cells, GATA-2 occupied a unique target gene ensemble, consisting of genes encoding key determinants of endothelial cell identity and inflammation. GATA-2-occupied sites characteristically contained motifs that bind Activator Protein-1 (AP-1), a pivotal regulator of

ORGANISM(S): Homo sapiens

SUBMITTER: Philip Cayting 

PROVIDER: E-GEOD-29531 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress