Transcription profiling of mouse keratinocytes expressing AhR to investigate inflammatory responses

ABSTRACT: Occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to provoke inflammatory and/or allergic disorders including asthma, rhinitis and dermatitis. The molecular mechanisms of this PAH-mediated inflammation remain to be clarified. Previous studies implied the involvement of PAHs as irritants and allergens, with the reactive oxygen species generated from the oxygenated PAHs believed to be an exacerbating factor. As well, the possibility exists that PAHs contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription, since PAHs are potent inducers of the AhR. To address this point, we generated transgenic mouse lines expressing the constitutive active form of the AhR in keratinocytes. In these li

ORGANISM(S): Mus musculus

SUBMITTER: Shogo Yamamoto 

PROVIDER: E-GEOD-2955 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress