Developmental underpinnings of differences in rodent novelty-seeking and emotional reactivity

ABSTRACT: Innate differences in human temperament strongly influence how individuals cope with stress and predispose for specific types of psychopathology. The present study examines the developing brain in an animal model of temperamental differences to understand how altered neurodevelopment may engender differences in emotional reactivity that are stable throughout the animal’s life. We utilize selectively-bred High Responder (bHR) and Low Responder (bLR) rats that exhibit dramatic emotional behavior differences, with bHRs exhibiting exaggerated novelty-exploration, aggression, impulsivity and drug self-administration, and bLRs showing marked behavioral inhibition, exaggerated anxiety- and depressive-like behavior. Using Affymetrix microarrays, we assessed bLR/bHR gene expression in the developin

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sarah Clinton 

PROVIDER: E-GEOD-29552 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress