Transcriptomic analysis of Clostridium thermocellum ATCC 27405 cellulose fermentation

ABSTRACT: Background: The ability of Clostridium thermocellum ATCC 27405 wild-type strain to hydrolyze cellulose and ferment the degradation products directly to ethanol and other metabolic byproducts makes it an attractive candidate for consolidated bioprocessing of cellulosic biomass to biofuels. In this study, whole-genome microarrays were used to investigate the expression of C. thermocellum mRNA during growth on crystalline cellulose in controlled replicate batch fermentations. Results: A time-series analysis of gene expression revealed changes in transcript levels of ~40% of genes (~1300 out of 3198 ORFs encoded in the genome) during transition from early-exponential to late-stationary phase. K-means clustering of genes with statistically significant changes in transcript levels identified six

ORGANISM(S): Clostridium thermocellum ATCC 27405

SUBMITTER: Babu Raman 

PROVIDER: E-GEOD-29554 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress