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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The expression level of microRNA after knockdown of Twist1 or Bmi1

ABSTRACT: To screen the microRNA regulated by Twist1 and Bmi1 Establish stable transfectants of pSUPER-sh-Twist1 or pSUPER-sh-Bmi1 in OECM1 cells and analyze the miRNA expression level of by microRNA microarray. OECM1 transfected with pSUPER-sh-scr was used as a control experiment.

ORGANISM(S): Homo sapiens

SUBMITTER: Muh-Hwa Yang

PROVIDER: E-GEOD-29586 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RAC1 activation mediates Twist1-induced cancer cell migration.

Yang Wen-Hao WH Lan Hsin-Yi HY Huang Chi-Hung CH Tai Shyh-Kuan SK Tzeng Cheng-Hwai CH Kao Shou-Yen SY Wu Kou-Juey KJ Hung Mien-Chie MC Yang Muh-Hwa MH

Nature cell biology 20120311 4

Epithelial-mesenchymal transition (EMT), which is characterized by the suppression of the adhesion protein E-cadherin, is a crucial process that promotes metastasis and stem-like properties of cancer cells. However, the dissociation of cellular aggregates is not sufficient to explain why cancer cells move, and the motile nature of cancer cells undergoing EMT remains elusive. Here, we identify a mechanism in which the EMT inducer Twist1 elicits cancer cell movement through activation of RAC1. Twi ...[more]

PMID: 22407364

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Homo sapiens

Project description:The expression level of microRNA after knockdown of Twist1 or Bmi1

| PRJNA141423 | ENA

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