Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mazen Karaman
PROVIDER: E-GEOD-2964 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lecane Philip S PS Karaman Mazen W MW Sirisawad Mint M Naumovski Louie L Miller Richard A RA Hacia Joseph G JG Magda Darren D
Cancer research 20051201 24
There is an emerging appreciation of the importance of zinc in regulating cancer cell growth and proliferation. Recently, we showed that the anticancer agent motexafin gadolinium (MGd) disrupted zinc metabolism in A549 lung cancer cells, leading, in the presence of exogenous zinc, to cell death. Here, we report the effect of MGd and exogenous zinc on intracellular levels of free zinc, oxidative stress, proliferation, and cell death in exponential phase human B-cell lymphoma and other hematologic ...[more]