Adenosine methylation is widespread throughout the transcriptome and prominent within 3' UTRs

ABSTRACT: Here, we use a novel technique for locating regions of N6-adenosine methylation (m6A) throughout the transcriptome and present a profile of m6A sites in the mouse brain. Our use of methylated RNA immunoprecipitation combined with RNA-seq (MeRIP-Seq) identifies thousands of RNAs which contain m6A sites. In addition, we find that regions of m6A formation are particularly enriched near stop codons, which might provide clues into the potential funciton of this highly prevalent RNA modificaiton. Examination of m6A sites in murine brain RNA.

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Mason 

PROVIDER: E-GEOD-29714 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress