The landscape of promoter DNA hypomethylation in liver cancer (expression data)

ABSTRACT: Extensive loss of DNA methylation is a hallmark of cancer. The role of hypomethylation in altering gene expression in cancer cells has been poorly understood. Hepatic cellular carcinoma (HCC) is one of the most common human cancers. We use HCC as a model to investigate hypomethylation in cancer by a combination of methylated DNA immunoprecipitation and hybridization with comprehensive promoter arrays. We identify approximately 2,800 promoters that are hypomethylated in tumor samples. The hypomethylated promoters appear in clusters across the genome suggesting a high-level organization behind the epigenomic changes in cancer. The genes whose promoters are demethylated are mainly involved in cell growth, cell adhesion and communication, signal transduction, mobility and invasion; functions t

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Suderman 

PROVIDER: E-GEOD-29721 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress