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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of bone marrow-derived macrophages from BALB/c and C57BL/6J mice with or without IFN-gamma treatment and then infection with Yersinia enterocolitica

ABSTRACT: BMDM from BAL/c and C57BL/6 BMDM were stimlated with IFN-g overnight and infected with different Yersinia strains for 3 hrs. Experiment Overall Design: 3-4 biological replicates were analyzed from each condition

ORGANISM(S): Mus musculus

DISEASE(S): Yersinia enterocolitica WAP infected (virulent)

SUBMITTER: Reinhard Hoffmann

PROVIDER: E-GEOD-2973 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Role of strain differences on host resistance and the transcriptional response of macrophages to infection with Yersinia enterocolitica.

van Erp Katrin K Dach Kristina K Koch Isabel I Heesemann Jürgen J Hoffmann Reinhard R

Physiological genomics 20051213 1

The outcome of a host-pathogen encounter is determined by virulence factors of the pathogen and defense factors of the host. We characterized the impact of host factors [resistant (C57BL/6) or susceptible (BALB/c) genetic background and exposure to interferon (IFN)-gamma] on transcriptional responses of bone marrow-derived macrophages (BMDM) to infection with Yersinia enterocolitica. IFN-gamma treatment more profoundly altered the transcriptome of BMDM than did bacterial infection or genetic bac ...[more]

PMID: 16352694

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