RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia

ABSTRACT: Epigenetic pathways regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. While chromatin alterations are, in principle, reversible and often amendable to drug intervention, the promise of targeting such pathways therapeutically has been hampered by our limited understanding of cancer-specific epigenetic dependencies. Here we describe a non-biased approach to probe epigenetic vulnerabilities in acute myeloid leukemia (AML) – an aggressive hematopoietic malignancy often associated with aberrant chromatin states. By screening a custom shRNA library targeting known chromatin regulators in a geneticall

ORGANISM(S): Homo sapiens

SUBMITTER: Junwei Shi 

PROVIDER: E-GEOD-29799 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress