Myocardial transcriptome analysis of human arrhythmogenic right ventricular cardiomyopathy (ARVC)

ABSTRACT: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy primarily of the right ventricle characterized through fibrofatty replacement of cardiomyocytes. The genetic etiology in ARVC patients is most commonly caused by dominant inheritance and high genetic heterogeneity. Though histological examinations of ARVC affected human myocardium reveals fibrolipomatous replacement, the molecular mechanisms leading to loss of cardiomyocytes are largely unknown. We therefore analyzed the transcriptomes of 6 ARVC specimen derived from heart transplantation candidates and compared our findings to 6 non-failing donor hearts (NF) which could not be transplanted for technical reasons. In addition, we compared our findings to 7 hearts from patients with idiopathic dilated cardi

ORGANISM(S): Homo sapiens

SUBMITTER: Patrick Schwientek 

PROVIDER: E-GEOD-29819 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress