Expression data from hypervitaminosis A rat diaphyseal bone

ABSTRACT: Vitamin A is the only known compound that produces spontaneous fractures in rats. In an effort to resolve the molecular mechanism behind this effect, we fed young rats high doses of vitamin A and performed a global transcriptional analysis of diaphyseal bone after one week, i.e. just before the first fractures appeared. Microarray gene expression analysis revealed that 68 transcripts were differentially expressed in hypervitaminotic cortical bone and 118 transcripts were found when the bone marrow was also included. 98% of the differentially expressed genes in the bone marrow sample were up-regulated. In contrast, hypervitaminotic cortical bone without marrow showed reduced expression of 37% of differentially expressed genes. Gene Ontology (GO) analysis revealed that only samples containin

ORGANISM(S): Rattus norvegicus

SUBMITTER: Anders Isaksson 

PROVIDER: E-GEOD-29859 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress