Daphnia magna exposed to narcotics and polar narcotics - isopropanol

ABSTRACT: Structural analogues are assumed to elicit toxicity via similar predominant modes of action (MOAs). Currently, MOA categorization of chemicals in environmental risk assessment is mainly based on the physico-chemical properties of potential toxicants. It is often not known whether such classification schemes are also supported by mechanistic biological data. In this study, the toxic effects of two groups of structural analogues (alcohols and anilines) with predefined MOA (narcotics and polar narcotics) were investigated at different levels of biological organization (gene transcription, energy reserves and growth). Chemical similarity was not indicative of a comparable degree of toxicity and a similar biological response. Categorization of the test chemicals based on the different biologica

ORGANISM(S): Daphnia magna

SUBMITTER: Nathalie Dom 

PROVIDER: E-GEOD-29864 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress