Expression data from amoeboid and ramified microglia isolated from the corpus callosum of 5-day and 4-week old rat brain

ABSTRACT: Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC) alongside several intermediate forms. The AMC are characterized by being proliferative, phagocytic and migratory whereas the RMC are quiescent and exhibit a slow turnover rate. The AMC transform into RMC with advancing age, and this transformation is indicative of the gradual shift in the microglial functions. Both AMC and RMC respond to CNS inflammation, and they become hypertrophic when they are activated by trauma, infection or neurodegenerative stimuli. The molecular mechanisms and functional significance of morphological transformation of

ORGANISM(S): Rattus norvegicus

SUBMITTER: S Thameem Dheen 

PROVIDER: E-GEOD-29885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress