Global Methylation Patterns in Idiopathic Pulmonary Fibrosis

ABSTRACT: Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease that affects more than 5 million people worldwide with a steady increase in both incidence and mortality. There is currently no effective therapy and the median survival without transplant is 2-5 years. The etiological factor is unknown, but several observational and pathogenesis studies suggest that environmental agents may cause IPF. DNA methylation is a type of chemical modification of DNA such environmental and occupational factors, that can induced a changes in the regulation of biological processes and link to diseases such as a cancer. We hypothesize that the global changes in methylation patterns of IPF lungs caused by environmental factors. In this study we will identify the global methylation signatures of

ORGANISM(S): Homo sapiens

SUBMITTER: Einat Rabinovich 

PROVIDER: E-GEOD-29895 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress