Glyco gene profiling of two Hela cell lines to help identify NKp30L expressed on tumoral cells

ABSTRACT: NKp30 is one of the first NK-specific triggering receptor involved in tumour cell lysis to be identified. It is part of the so-called Natural Cytotoxicity Receptors (NCRs) also including NKp44, NKp46 and NKp80 (Bottino, 2005). Human NKp30 is a 190 amino-acids transmembrane protein with an extracellular V-type Ig-like domain containing two putative N-glycosylation sites (Pende, 1999). Three alternative splices can yield three different intracellular domains. An additional alternative splice can induce the deletion of 25 AA in the extracellular domain leading to the formation of a predicted C2-type Ig-like domain instead of a V-type Ig-like domain (Hollyoake, 2005; Neville, 1999). Dr. Romagne lab's aim is to identify NKp30L expressed on tumoral cells. Preliminary Results: Two in vitro system

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Head 

PROVIDER: E-GEOD-29930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress