Thermoprotection in the Drosophila hsf4 mutant

ABSTRACT: In Drosophila larvae, acquired synaptic thermotolerance following heat shock has previously been shown to correlate with the induction of heat shock proteins (Hsps) including HSP70. We tested the hypothesis that synaptic thermotolerance would be significantly diminished in a temperature-sensitive strain (hsf4) which has been reported not to be able to produce inducible Hsps in response to heat shock. Contrary to our hypothesis, considerable thermoprotection was still observed at hsf4 larval synapses following heat shock. To investigate the cause of this thermoprotection, we conducted DNA microarray experiments to identify heat-induced transcript changes in these organisms. Transcripts of the hsp83, dnaJ-1(hsp40) and gstE1 genes were significantly up-regulated in hsf4 larvae after heat sho

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Scott Neal 

PROVIDER: E-GEOD-2998 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress