Renal Cell Carcinoma Differential Expression

ABSTRACT: We investigated the changes in gene expression accompanying the development and progression of kidney cancer using 31,500 element complementary DNA arrays. We measured expression profiles for paired neoplastic and non-cancerous renal epithelium samples from 37 individuals. Using an experimental design optimized for factoring out technological and biological noise, and an adapted statistical test, we find 1738 differentially expressed cDNAs with an expected number of 6 false positives. Functional annotation of these genes provided views of the changes in the activities of specific biological pathways in renal cancer. Cell adhesion, signal transduction, and nucleotide metabolism were among the biological processes with a large proportion of genes overexpressed in renal cell carcinoma. Downre

ORGANISM(S): Homo sapiens

SUBMITTER: Martin Vingron 

PROVIDER: E-GEOD-3 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress