Deregulation of Gene Expression induced by Environmental Tobacco Smoke Exposure in Pregnancy

ABSTRACT: Passive smoke intake by pregnant women may have detrimental effects such as spontaneous abortion, lower birth weight, stillbirth, and reduced infant lung function. To extend our knowledge on molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them to those in active smokers (AS). Using Illumina Expression Beadchip with 24,526 transcript probes, gene expression patterns were assayed in placentas from PS (N=25) exposed to environmental tobacco smoke (ETS) throughout pregnancy and non-exposed (NS) counterparts (N=35), and in cord blood cells from their newborns. The ETS exposure was evaluated by questionnaire disclosure and cotinine measurement in maternal and cord bloods. A total of 196 genes were significantl

ORGANISM(S): Homo sapiens

SUBMITTER: Hana Bruchova 

PROVIDER: E-GEOD-30032 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress