Cultured human amniotic fluid-derived mesenchymal stromal cells [miRXplore data]

ABSTRACT: Human amniotic fluid-derived mesenchymal stromal cells (hAMSC) have become one of the main cell populations used in regenerative medicine and for the study of various clinical disorders. These cells have a great capacity for proliferation and differentiation, do not form teratomas when transplanted into animal models and their stemness seems to be between embryonic cells and adult mesenchymal cells. Prior to their use in cell therapy they must be cultured and expanded in vitro, but the effect this process has on their fitness, a determining factor for the success or failure of cell therapy, is unknown. We undertook a follow-up of gene and microRNAs (miRNAs) expression using microarray of a hAMSC population kept under in vitro culture conditions for the first 15 passages. Significant change

ORGANISM(S): synthetic construct

SUBMITTER: Jose Maria Miranda-Sayago 

PROVIDER: E-GEOD-30065 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress