AIRE-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis

ABSTRACT: Mutations in the gene encoding the transcription factor AutoImmune REgulator (AIRE) are responsible for the ‘Autoimmune PolyEndocrinopathy Candidiasis Ecodermal Dystrophy’ syndrome. AIRE directs expression of tissue restricted antigens in the thymic medulla and in lymph node stromal cells and thereby substantially contributes to induction of immunological tolerance to self-antigens. Data from experimental mouse models showed that AIRE-deficiency leads to impaired deletion of autospecific T cell precursors. However, a potential role for AIRE in the function of regulatory T cell populations, which are known to play a central role in prevention of immunopathology, has remained elusive. Regulatory T cells of CD8+CD28low phenotype efficiently control immune responses in experimental autoimmune

ORGANISM(S): Mus musculus

SUBMITTER: Mark Van der Hoek 

PROVIDER: E-GEOD-30129 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress