Transcription profiling of endometrial epithelial cells (EECs) to understand actions of tamoxifen in the uterus and its molecular effectors in endometrial carcinogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): endometrioid carcinoma
SUBMITTER: Yongfeng Shang
PROVIDER: E-GEOD-3013 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis.
Wu Huijian H Chen Yupeng Y Liang Jing J Shi Bin B Wu Ge G Zhang Ying Y Wang Dan D Li Ruifang R Yi Xia X Zhang Hua H Sun Luyang L Shang Yongfeng Y
Nature 20051201 7070
Tamoxifen, a selective oestrogen receptor modulator, has been used in the treatment of all stages of hormone-responsive breast cancer. However, tamoxifen shows partial oestrogenic activity in the uterus and its use has been associated with an increased incidence of endometrial cancer. The molecular explanation for these observations is not known. Here we show that tamoxifen and oestrogen have distinct but overlapping target gene profiles. Among the overlapping target genes, we identify a paired- ...[more]
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