The RANK IVVY Motif-regulated Genes in Osteoclastogenesis

ABSTRACT: By carrying out a systematic structure/function study of the RANK cytoplasmic domain, we previously identified a specific 4-a.a. RANK motif (IVVY535-538) which plays a critical role in osteoclastogenesis by mediating commitment of macrophages to the osteoclast lineage. We have recently validated the role of this IVVY motif in osteoclastogenesis in vivo by generating knockin (KI) mice bearing inactivating mutations in the RANK IVVY motif. This microarray experiment was performed to determine whether the IVVY motif is involved in regulating gene expression in osteoclastogenesis. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. Bone marrow macrophages isolated from wild-t

ORGANISM(S): Mus musculus

SUBMITTER: Dongquan Chen 

PROVIDER: E-GEOD-30160 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress