Molecular-genetic correlates of fatigue in cancer patients receiving localized external beam radiation therapy

ABSTRACT: The etiology behind cancer-related fatigue (CRF) is currently unknown. The physiological mechanisms of CRF are based on limited evidence that genetic factors, energy expenditure, metabolism, aerobic capacity, and the individual's immune response to inflammation are responsible for the experience of CRF. Gene expression profiling using microarray analysis from white blood cells of men with non-metastatic prostate cancer shows significant, differential expression of 463 probesets during localized external beam radiation therapy (EBRT). Pathway analysis shows a central role of SNCA (alpha-synuclein gene) among these differentially expressed probesets. Significant expression of SNCA was confirmed by qPCR (p<.001) and ELISA (p<.001) over time during EBRT. A significant correlation was noted bet

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Barb 

PROVIDER: E-GEOD-30174 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress