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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression analysis of mantle cell lymphoma (MCL) combined with laser microdissection

ABSTRACT: Wnt3 signaling pathway plays a central role in lymphomagenesis, and that specific mitotic regulators facilitate transformation into more aggressive forms. For initiation, we compared the tumor cells of MCL in situ (n=4) with normal mantle zone B-lymphocytes (n=4), which were selected by laser microdissection.For transformation, we selected the overlapping genes differentially expressed between both cMCL (n=4) vs aMCL (n=5) and classical vs aggressive areas in iMCL (n=2).

ORGANISM(S): Homo sapiens

SUBMITTER: Yoshizo Kimura

PROVIDER: E-GEOD-30189 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression analysis of mantle cell lymphoma (MCL) combined with laser microdissection

Project description:Wnt3 signaling pathway plays a central role in lymphomagenesis, and that specific mitotic regulators facilitate transformation into more aggressive forms.

2011-06-25 | GSE30189 | GEO

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Project description:Mantle cell lymphoma (MCL) is an aggressive neoplasm with poor outcome. However, some patients have an indolent disease (iMCL) and may not require intensive treatment at initial diagnosis. Diagnostic criteria to recognize these patients are not available. We hypothesized that the analysis of the genetic and expression features of the tumors may help to identify patients with an indolent clinical evolution and provide biomarkers that could be used in the clinical setting. Seven patients with an iMCL that did not require chemotherapy for more than 2 years were compared to 15 conventional MCL (cMCL) that needed systemic therapy at diagnosis. MCL were compared with other leukemic lymphoid neoplasms including 17 CLL, 7FL, HCL and 2HCLv.

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A defect of the INK4-Cdk4 checkpoint and c-myc collaborate in blastoid mantle cell lymphoma (MCL)-like lymphoma formation in mice

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The Gene Expression Study (GEP) was based on a 6 MCL cell line models.

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MCL cell line Mino +/- Palbociclib +/-cyclin D1siRNA

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