The transcriptional profile of Langhans-like multinucleated giant macrophages: Collapse of the inflammatory and immune responses

ABSTRACT: Monocytes/macrophages have the ability to fuse in multinucleated giant cells (MGCs). Except for osteoclasts that resorb bones on large surfaces, the function of other macrophage-derived MGCs, which appear under pathological situations associated with granulomatous inflammation such as tuberculosis, is not understood. Here we deciphered functions and gene expression profiles of MGCs obtained after stimulation of human monocytes with IFN-gM-BM- and concanavalin A. First, we show that the competence of MGCs in phagocytosis and O2- production was similar to those of monocytes-derived macrophages (MDMs) and that MGCs exhibited a M1 polarization. Second, we analyzed the transcriptional profile of MGCs using gene categories and the building of gene networks. The signature of MGCs was markedly dis

ORGANISM(S): Homo sapiens

SUBMITTER: adil ef 

PROVIDER: E-GEOD-30273 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress