Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Study of microRNA associated with metforminM-bM-^@M-^Ys anti-tumor effect

ABSTRACT: The miRNAs expression was markedly altered with the treatment of metformin in vitro and in vivo and various miRNAs induced by metformin also may contribute to tumor growth in vitro and in vivo. Using a custom microarray platform, we analyzed the expression levels of 985 human miRNA probes in the cell lines in vitro and tumorous tissues in vivo that were treated with and without metformin.

ORGANISM(S): Homo sapiens

SUBMITTER: Satoshi Kondo 

PROVIDER: E-GEOD-30289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Recent studies suggest that metformin, which is commonly used as an oral anti-hyperglycemic agent of the biguanide family, may reduce cancer risk and improve prognosis, but the mechanisms by which metformin affects various cancers, including gastric cancer, remains unknown. The goal of the present study was to evaluate the effects of metformin on human gastric cancer cell proliferation in vitro and in vivo and to study microRNAs (miRNA) associated with antitumor effect of metformin. We used MKN1  ...[more]

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