The histotype-specific copy-number landscape of ovarian cancer (copy number SNP)

ABSTRACT: Ovarian cancer is characterized by multiple structural aberrations; most are passenger alterations which do not confer tumor growth. Like many cancers, it is a heterogeneous disease and till date, the histotype-specific copy number landscape has been difficult to elucidate. To dissect the heterogeneity of ovarian cancer and understand the pathogenesis of its various histotypes, we developed an in silico hypothesis-driven workflow to identify histotype-specific copy number aberrations across multiple datasets of epithelial ovarian cancer. In concordance with previous studies on global copy number changes, our study showed similar alterations. However, when the landscape was de-convoluted into histotypes, distinct alterations were observed. We report here a comprehensive histotype-speci

ORGANISM(S): Homo sapiens

SUBMITTER: Liang Goh 

PROVIDER: E-GEOD-30300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress