DMSO control and DZNep treated MOLM-14 cells

ABSTRACT: We demonstrated that 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, induce robust apoptosis in AML cells through increased ROS production and ER stress. We identified a core gene signature including TXNIP, a major redox control molecule which is crucial in DZNep-induced apoptosis. MOLM-14 cells were treated with DMSO and DZNep 2 µM for 24 hours

ORGANISM(S): Homo sapiens

SUBMITTER: Jianbiao Zhou 

PROVIDER: E-GEOD-30315 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress