RNA-seq of 6 tissues from 10 species to investigate the evolution of gene expression levels in mammalian organs

ABSTRACT: Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromo

ORGANISM(S): Gallus gallus

SUBMITTER: Henrik Kaessmann 

PROVIDER: E-GEOD-30352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress