Gene expression data from sorted and unsorted primary human acute myeloid leukemia (AML) samples

ABSTRACT: Experiments using xenografts show that some solid tumours and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSC). Despite promise, the relevance of the CSC model to human disease remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model based on sorting multiple populations from each of 16 primary human AML samples and identifying which contain leukemia stem cells (LSC) using a sensitive xenograft assay. Analysis of gene expression from all functionally validated populations yielded an LSC-specific signature. Similarly, a hematopoietic stem cell (HSC) gene signature was established. Bioinformatic analysis identified a core transcriptional program shared by LSC and HSC, revealing the molecular machinery underlying stemness proper

ORGANISM(S): Homo sapiens

SUBMITTER: Kolja Eppert 

PROVIDER: E-GEOD-30375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress