Ustilago maydis rak1 mediated gene expression during exponential growth

ABSTRACT: In mammalian cells RACK1 serves as a scaffold protein that has a role in integrating inputs from different signaling pathways and affects translation through association with ribosomes. U. maydis contains a seven-WD40 repeat motif protein designated Rak1, which shows 68% identity to RACK1 and is homologous to Asc1p of Saccharomyces cerevisiae. The asc1 mutant could be complemented by introduction of U. maydis rak1. The deletion of rak1 affected cell growth, cell wall integrity and specifically attenuated cell fusion. This latter defect was caused by reduced expression of prf1 encoding the regulator for pheromone and pheromone-receptor genes. Rak1 interacts with a variety of ribosomal proteins and microarray analysis revealed that the deletion of rak1 led to severely reduced expression of r

ORGANISM(S): Ustilago maydis

SUBMITTER: Regine Kahmann 

PROVIDER: E-GEOD-30382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress