Gene expression profiling of mammary epithelial cells and their role in the predisposition to Staphylococcus aureus infections

ABSTRACT: Background: Staphylococcus aureus is a major pathogen of humans and animals. Host genetics influence the susceptibility to S. aureus infections, and genes determining infection outcome remain to be identified. Here, we used outbred animals from a divergent selection on susceptibility towards Staphylococcus infection to explore host immunogenetics. Methodology/Principal Findings: We investigated in vitro how mammary epithelial cells (MEC) respond to live S. aureus or S. aureus supernatant and whether MEC from animals with different degree of susceptibility to intra-mammary infections have distinct gene expression profiles. We measured the expression of 15K probes in MEC after each kind of stimulation (living bacteria or culture supernatant) at three different time points (a reference withou

ORGANISM(S): Ovis aries

SUBMITTER: Cécile Bonnefont 

PROVIDER: E-GEOD-30390 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress