Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state

ABSTRACT: DNA replication programs have been studied extensively in yeast and animal systems, where they have been shown to correlate with gene expression and certain epigenetic modifications. Despite the conservation of core DNA replication proteins, little is known about replication programs in plants. We used flow cytometry and tiling microarrays to profile DNA replication of Arabidopsis thaliana chromosome 4 (chr4) during early, mid, and late S phase. Replication profiles for early and mid S phase were similar and encompassed the majority of the euchromatin. Late S phase exhibited a distinctly different profile that includes the remaining euchromatin and essentially all of the heterochromatin. Termination zones were consistent between experiments, allowing us to define 163 putative replicons on

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Pete Pascuzzi 

PROVIDER: E-GEOD-30433 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress