Retroviral Sox17 over-expression adult hematopoietic stem/progenitor cells microarray

ABSTRACT: The transcription factor SOX17 is expressed by fetal, but not adult hematoipoietic stem cells (HSCs), and is required for the maintenance of fetal and neonatal, but not adult, HSCs. In the current study we show that ectopic expression of Sox17 in adult HSCs and transiently reconstituting multipotent progenitors was sufficient to confer increased self-renewal potential and the expression of fetal HSC genes including fetal HSC surface markers. To assess the mechanisms by which ectopic Sox17 expression in adult hematopoietic progenitors increased self-renewal potential and conferred fetal HSC properties, we compared the gene expression profiles of E16.5 fetal liver HSCs, young adult bone marrow HSCs, young adult bone marrow CD48+LSK cells, and Sox17-expressing CD48+LSK cells isolated from mic

ORGANISM(S): Mus musculus

SUBMITTER: Shenghui He 

PROVIDER: E-GEOD-30444 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress