The nucleosome remodeler SNF2L modulates WNT signaling for cellular homeostasis

ABSTRACT: ISWI is an evolutionary conserved ATPase that catalyzes nucleosome remodeling in several different complexes. Two mammalian ISWI orthologs, SNF2H and SNF2L, have specialized functions despite their high similarity. Due to the lack of reagents the functions of SN2L in human cells had not been established. Newly established specific monoclonal antibodies and selective RNA interference protocols now enabled a comprehensive characterization of loss-of-function phenotypes in human cells. Contrasting earlier results obtained in the mouse model, we found SNF2L broadly expressed in primary human tissues. Depletion of SNF2L in HeLa cells led to enhanced proliferation, morphological alterations and increased migration. These phenomena were explained by transcriptome profiling, which identified SNF2

ORGANISM(S): Homo sapiens

SUBMITTER: Tobias Straub 

PROVIDER: E-GEOD-30471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress