Myc and Miz-1 control melanocyte senescence by regulating intracellular cystathionase levels

ABSTRACT: The development of malignant melanoma is a highly complex process which is still poorly understood despite extensive research. A majority of human melanomas are found to express a handful of oncogenic proteins, such as mutant RAS and BRAF. However, these oncogenes are also found in nevi, and it is now a well-accepted fact that their expression alone leads to senescence. This renders the understanding of senescence escape mechanisms an important criterion to understand tumor development. Here, we describe the ability of the transcription factor MYC to drive the evasion of reactive oxygen stress-induced melanocyte senescence, caused by activated receptor tyrosine kinase signaling. Conversely, MIZ1, the growth suppressing interaction partner of MYC, is involved in mediating melanocyte senes

ORGANISM(S): Mus musculus

SUBMITTER: Susanne Kneitz 

PROVIDER: E-GEOD-30473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress