Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

ABSTRACT: The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family1, 2, but less is known about the role of other histone modifications in longevity. Histone methylation has a crucial role in development and in maintaining stem cell pluripotency in mammals3. Regulators of histone methylation have been associated with ageing in worms4, 5, 6, 7 and flies8, but characterization of their role and mechanism of action has been limited. Here we identify the ASH-2 trithorax complex9, which trimethylates histone H3 at lysine 4 (H3K4), as a regulator of lifespan in Caenorhabditis elegans in a directed RNA interference (RNAi) screen in fertile

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Eric Greer 

PROVIDER: E-GEOD-30505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress