Transcription profiling of human HeLa cell line response to hypoxia

ABSTRACT: Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular level, including the alteration of gene expression. Astrocytes play critical roles in the proper functioning of the brain, thus the manner in which astrocytes respond to hypoxia is likely important in determining the outcome of brain hypoxia. We used microarray gene expression profiling and data analysis algorithms to identify and analyze hypoxia-responsive genes in primary human astrocytes. We also compared the gene expression patterns in astrocytes with those in human HeLa cells and pulmonary artery endothelial cells (ECs). Remarkably, in astrocytes, 5 times as many genes were up-regulated as

ORGANISM(S): Homo sapiens

SUBMITTER: Sarah Mense 

PROVIDER: E-GEOD-3051 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress