Influence of short-time feeding of rats with an iron-deficient diet on their hepatic gene expression profiles

ABSTRACT: Iron deficiency-induced anemia is generally a representative nutritional problem in most populations. We reported that the anemia due to dietary iron deficiency causes a variety of changes in nutrient metabolism, even leading to apoptosis as a result of associated endoplasmic reticulum (ER) stress in the rat liver. On the other hand, it appears that non-anemic iron-deficiency causes no serious problem because no appreciable down-regulation of hemoglobin synthesis occurs. Biochemically, iron is essential for activation of cytochrome-related enzymes and its deficiency should yield some physiological problems. We performed a comprehensive transcriptome analysis to define the effects of non-anemic iron deficiency on hepatic gene expression. Four-week-old rats were fed a low-iron diet (ca. 3 p

ORGANISM(S): Rattus norvegicus

SUBMITTER: Asuka Kamei 

PROVIDER: E-GEOD-30533 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress