Expression data from parietal cortex of G114V genetic Creutzfeldt-Jakob disease patient

ABSTRACT: The familial or genetic Creutzfeldt-Jakob disease (fCJD or gCJD) is the inherent form of human prion diseases, which accounts for approximately 10-15% of human prion diseases that are caused by mutations of the prion protein gene (PRNP). In this study, the global expression patterns of the parietal cortex from a patient with G114V gCJD were comparatively analyzed with the normal controls by using a commercial human genome expression chip. Totally 8774 genes showed differential expression, among them 2769 genes were upregulated and 6005 ones were downregulated. The reliability of the results was confirmed by the real-time RT-PCR assays for several specific genes. The most differentially expressed genes involved in the functions of regulation of transcription, ion transport, transcription, c

ORGANISM(S): Homo sapiens

SUBMITTER: chan tian 

PROVIDER: E-GEOD-30643 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress