Context-Specific Regulation of NF-?B Target Gene Expression by EZH2 in Breast Cancers

ABSTRACT: Both EZH2 and NF-?B contribute to aggressive breast cancer, yet whether the two oncogenic factors have functional cross-talk in breast cancer is largely unknown. Here, we uncover an unexpected role of EZH2 in conferring the constitutive activation of NF-?B target gene expression in ER-negative basal-like breast cancer cells. This function of EZH2 is independent of its histone methyltransferase activity but requires the physical interaction with RelA/RelB to promote the expression of NF-?B targets. Intriguingly, EZH2 acts oppositely in repressing NF-?B targets in ER-positive luminal-like breast cancer cells by interacting with ER and directing repressive histone methylation. Thus, EZH2 function as a double-facet molecule in breast cancers, functioning either as a transcriptional activator

ORGANISM(S): Homo sapiens

SUBMITTER: Peiyong Guan 

PROVIDER: E-GEOD-30670 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress