Stem Cell Antigen-1 (Sca-1) Regulates Mammary Tumor Development and Cell Migration
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chad Creighton
PROVIDER: E-GEOD-30684 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration.
Batts Torey D TD Machado Heather L HL Zhang Yiqun Y Creighton Chad J CJ Li Yi Y Rosen Jeffrey M JM
PloS one 20111129 11
<h4>Background</h4>Stem cell antigen-1 (Sca-1 or Ly6A) is a glycosyl phostidylinositol (GPI)-anchored cell surface protein associated with both stem and progenitor activity, as well as tumor initiating-potential. However, at present the functional role for Sca-1 is poorly defined.<h4>Methodology/principal findings</h4>To investigate the role of Sca-1 in mammary tumorigenesis, we used a mammary cell line derived from a MMTV-Wnt1 mouse mammary tumor that expresses high levels of endogenous Sca-1. ...[more]
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