Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1

ABSTRACT: Not all patients with nerve injury develop neuropathic pain. The extent of nerve damage and age at the time of injury are two of the few risk factors identified to date. In addition, preclinical studies show that neuropathic pain variance is heritable. To define such factors further, we performed a large-scale gene profiling experiment which plotted global expression changes in the rat dorsal root ganglion in three peripheral neuropathic pain models. This resulted in the discovery that the potassium channel alpha subunit KCNS1, involved in neuronal excitability, is constitutively expressed in sensory neurons and markedly downregulated following nerve injury. KCNS1 was then characterized by an unbiased network analysis as a putative pain gene, a result confirmed by single nucleotide polymor

ORGANISM(S): Rattus norvegicus

SUBMITTER: Giovanni Coppola 

PROVIDER: E-GEOD-30691 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress