The Streptomyces lividans lsp mutant

ABSTRACT: The Streptomyces lividans lsp gene encodes a type II signal peptidase (Lsp) that cleaves the type II leader peptides of lipoproteins. Transcriptional profiling of the bacterium depleted of the lsp gene mainly resulted in deactivation of the sigma U regulon, as well as in downregulation of genes involved in the biogenesis and function of ribosomes and genes encoding some major secretory proteins as determined by hybridisation of commercially available S. lividans genome-wide microarrays. Almost 50% of the dowregulated genes have been described as forming part of the stringent response in streptomycetes. The gene encoding the S. lividans extracellular foldase, the lipoprotein FkpA, is equally downregulated. Therefore, the deletion of lsp from the S. livdans genome temporarily triggers a cell

ORGANISM(S): Streptomyces lividans

SUBMITTER: Sonia GullM-CM-3n 

PROVIDER: E-GEOD-30728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress