Expression data from murine acute myeloid leukemia (AML) cells following shRNA-mediated suppression of Myb

ABSTRACT: Using an integrative approach combining a Tet-off conditional AML mouse model, global expression profiling following suppression of the driving MLL-AF9 oncogene, and a new Tet-on conditional shRNA expression system we have identified Myb as critical mediator of addiction to MLL-AF9. Suppression of Myb in established AML in vivo terminates aberrant self-renewal and triggers a terminal myeloid differentiation program that precisely phenocopies the effects of suppressing MLL-AF9. Remarkably, suppressing Myb effectively eradicates aggressive and chemotherapy resistant AML. To further investigate Myb dependent transcriptional programs involved in mediating aberrant self-renewal in leukemia, we globally surveyed gene expression changes following acute shRNA-induced suppression of Myb in an estab

ORGANISM(S): Mus musculus

SUBMITTER: Johannes Zuber 

PROVIDER: E-GEOD-30745 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress