E-GEOD-30764 - RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice. - OmicsDI

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.

ABSTRACT: The goal was to find genes which are differentially expressed between the naked mole-rat (Heterocephalus glaber) and the wild-type mice liver tissue. The genes which are most differentially expressed may provide a clue for the remarkable differences between naked mole-rat and mouse in terms of longevity, cancer resistance and adaptation to subterranean environments. Analysis of 2 mRNA samples, one pooled from 3 wild-type mice liver tissue and another pooled from 3 naked mole-rat liver tissue.

ORGANISM(S): Heterocephalus glaber

SUBMITTER: Yang Li

PROVIDER: E-GEOD-30764 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.

Yu Chuanfei C Li Yang Y Holmes Andrew A Szafranski Karol K Faulkes Chris G CG Coen Clive W CW Buffenstein Rochelle R Platzer Matthias M de Magalhães João Pedro JP Church George M GM

PloS one 20111103 11

The naked mole-rat (Heterocephalus glaber) is a long-lived, cancer resistant rodent and there is a great interest in identifying the adaptations responsible for these and other of its unique traits. We employed RNA sequencing to compare liver gene expression profiles between naked mole-rats and wild-derived mice. Our results indicate that genes associated with oxidoreduction and mitochondria were expressed at higher relative levels in naked mole-rats. The largest effect is nearly 300-fold higher ...[more]

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