Impaired endosomal recycling in proximal tubules is mechanistically linked to proteinuria

ABSTRACT: Through substitution mapping studies, we previously identified that a <330kb region from a rat strain with no renal pathology (the Lewis rat), which when introgressed onto the genetic background of a rat with renal disease (the Dahl Salt-sensitive (S) rat), caused an increase rather than the expected decrease in proteinuria. The purpose of this study was to prioritize a candidate gene and further delineate the mechanism underlying the observed increased in proteinuria. A higher level of proteinuria independent of dietary salt was observed in the congenic rat at a very young age (50-52 day old). The critical congenic segment was further mapped to <42.5kb containing a single candidate gene, rififylin. Rififylin was expressed 1.59 fold higher in the congenic strain compared with S. Overexpres

ORGANISM(S): Rattus norvegicus

SUBMITTER: Bina Joe 

PROVIDER: E-GEOD-30770 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress