Expression profiling in VCP-associated myopathy

ABSTRACT: Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD) is caused by mutations in the Valosin Containing Protein (VCP) gene on chromosome 9p12-13. To elucidate affected signaling transduction axes in IBMPFD, we determined expression profiles using microarray technology in quadriceps muscle from patients and unaffected relatives. Muscle from 10 individuals (7 affected, 3 unaffected first degree relatives) was obtained after informed consent for the muscle biopsy was obtained.

ORGANISM(S): Homo sapiens

SUBMITTER: Svetlana Ghimbovschi 

PROVIDER: E-GEOD-30806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress