Analysis of liver gene expression profile in male mice fed alcoholic (Lieber-Decarli's) diet and calorie-matched control diet for 6 weeks
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: kalpana ghoshal
PROVIDER: E-GEOD-30829 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.
Kutay Huban H Klepper Corie C Wang Bo B Hsu Shu-hao SH Datta Jharna J Yu Lianbo L Zhang Xiaoli X Majumder Sarmila S Motiwala Tasneem T Khan Nuzhat N Belury Martha M McClain Craig C Jacob Samson S Ghoshal Kalpana K
PloS one 20120808 8
<h4>Background</h4>Methylation at C-5 (5-mdC) of CpG base pairs, the most abundant epigenetic modification of DNA, is catalyzed by 3 essential DNA methyltransferases (Dnmt1, Dnmt3a and Dnmt3b). Aberrations in DNA methylation and Dnmts are linked to different diseases including cancer. However, their role in alcoholic liver disease (ALD) has not been elucidated.<h4>Methodology/principal findings</h4>Dnmt1 wild type (Dnmt1(+/+)) and hypomorphic (Dnmt1(N/+)) male mice that express reduced level of ...[more]
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